Dependence on opioids is both physical and psychological. This means that the body becomes physically addicted and the person also feels that he or she needs the drugs in order to function. People who are addicted may have tried to stop using the drugs on their own and been unable to quit. Other signs of addiction include giving up activities or responsibilities in order to use the drug or as a result of the drug use. People addicted to opioids may also engage in a variety of behaviors to obtain more drugs, such as seeing a variety of physicians in order to obtain prescriptions. They may also continue to use the drugs despite negative consequences.

Some people may be more likely to develop dependence on opioids, such as those with a family history of drug addiction. Addiction occurs because these drugs make people feel good, and they want to maintain those feelings. Long-term use can create permanent changes in the brain. As with some other drug addictions, a person's tolerance level increases, so he or she needs to use more of the drug in order to reach the desired effects.

Treatment for opioid dependence requires that the person stop taking the drugs. Side effects of withdrawal can be difficult, and varieties of treatment options are available. Some medications can help ease withdrawal symptoms. Other options, including support groups such as Narcotics Anonymous and counseling can also be helpful.