Cocaine’s short-range physiological effects are dilated pupils, blood vessels that are constricted, high blood pressure, heart rate and temperature. Vast quantities of cocaine such as hundreds of milligrams of it more, can not only increase one’s high, but can also cause violent, erratic and bizarre behavior in a person. Such users can feel paranoia, muscle twitches, vertigo, tremors or, with repeated doses, a toxic reaction closely resembling amphetamine poisoning. Repeated intake can lead to amphetamine poisoning-like toxic reaction.

Sometimes cocaine also causes irritability, anxiety and restlessness. Sudden deaths, though rare, may occur on its first use or unexpectedly thereafter, probably due to a seizure, or cardiac arrest followed by a respiratory seize.

With its use there can be serious medical complications. The most common ones are respiratory problems like respiratory failure and chest pains, gastrointestinal complications like nausea and abdominal pain, cardiovascular problems, such as heart attacks and disturbance in the heart’s rhythm and neurological effects, like headaches, seizures and strokes.

Various heart diseases link to cocaine. It may cause chaotic heart rhythms, known as ventricular fibrillation, increase body temperature and blood pressure or   accelerate breathing and heart beat. Some physical symptoms may be nausea, chest pain, convulsions, muscle spasms, fever, blurred visions and even death and coma.