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  • Articles > Therapy & Treatment News > Molecular Switch May Control Addiction

    Researchers at the University of Toronto report that they have discovered a molecular “addiction switch” which may potentially be able to control addiction in substance abusers. An article for United Press International, released on February 26, 2006, cites a report published on January 18, 2006 in an online edition of Nature Neuroscience, which states that “a region of the brain called the VTA contains receptors that, when exposed to a certain enzyme, can control the switch from an addicted to non-addicted state and back again.”
    Up until this point, notes lead researcher Steven Laviolette, most doctors believed that addiction would cause a permanent change in the brain and that such a switch from one state to another would be impossible. 

    "Our findings suggest that instead of a permanent alteration in the brain, there's actually a switch that goes on between two separate systems (one that mediates the brain's response to drugs while not yet addicted and the other that mediates response once addicted)," says Laviolette.

    "They also suggest we may be able to manipulate that switch pharmacologically to take drug addicts back to a non-addicted state in a relatively short period of time so they do not crave the drug."

    Tests on lab rats showed that, with the use of certain drugs, scientists/researchers were able to switch the brains of the animals back to a non-addicted state in just a matter of hours, rather than the weeks or even months that it normally takes after a period of withdrawal from drugs. 

    This finding offers much hope in the burgeoning war to fight drug and alcohol addiction, offering much simpler and cost-effective solutions to these problems.  Usual treatment for serious drug abusers involves costly in- or out-patient rehabilitative services or self-help 12-step programs, like Alcoholics or Narcotics Anonymous.  
     




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    Addictions              Reply to this Comment
    I have studied and worked in the rehabilitation field of recovery. The paradigm of addictions is mor ethen just biological. There is a spiritual, mental , physical and emotional side to this disorder. The biggest misjudgement is that it is not a Moral Issue!! It is a repititous cycle that is effecting certain people that have a genetic disposition to it. Not the fact that regular people dont have issues.The chemically dependant individual is extreme and very predictable. As human he is relationally sick and has put his or her addiction before loved ones and important priorioties. Priorities ??? what is that!! I have no quotes for my writing but im assured that anyone from this background will relate to this as cancer.We must look to solutions and treat this with extreme awareness. In Canada as other countries im well travelled and have seen the differences between normal and compulsive behavior. Also I have lived and tried to live AA principals and steps in my life. It is good we are looking for soutions to a ever growing problem and we have to be aware that there is alot more then the chemical based approach to treating this problem. Preston



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